Place the pineapple juice, brown sugar, soy sauce, ketchup, garlic powder, and ginger into a large measuring cup or bowl. Whisk to combine.
1 ½ cups pineapple juice, ¾ cup light brown sugar, ¾ cup soy sauce, 3 tablespoons ketchup, 1 teaspoon garlic powder, ½ teaspoon ground ginger