Preheat your oven to 425°F. Line a large baking sheet with foil and place a wire rack on top then spray the wire rack with cooking spray.
Brush mayonnaise on both sides of each chicken breast.
4 thinly sliced chicken breasts, 2 tablespoons mayonnaise
In a large bowl, combine the panko breadcrumbs, grated Parmesan cheese, Italian seasoning, garlic powder, salt, and black pepper. Stir in the melted butter until the mixture is well combined.
3 cups panko breadcrumbs, 1 cup grated Parmesan cheese, 1 ½ tablespoons Italian seasoning, 1 teaspoon garlic powder, 1 teaspoon salt, ½ teaspoon ground black pepper, 4 tablespoons unsalted butter
Press each chicken breast into the panko mixture, ensuring it's fully coated on all sides. Place the coated chicken breasts on the wire rack.
Bake in the preheated oven for 20-25 minutes, or until the chicken reaches an internal temperature of 165°F and the coating is golden and crispy. Adjust the time as needed depending on the thickness of the chicken.
Optional: For an extra crispy breading, broil the chicken for 1-2 minutes after baking. Keep a close eye on it to ensure the coating gets nicely browned without drying out the chicken.
Remove from the oven and let the chicken rest for a few minutes before serving.