Soak the Fish: In a shallow dish, whisk together the buttermilk and hot sauce. Add the catfish fillets and let them soak for 15–30 minutes while you prep the breading.
1 cup buttermilk, 1 tablespoon hot sauce, 4 catfish fillets
Prepare the Breading: In another shallow dish, mix the cornmeal, flour, garlic powder, smoked paprika, salt, and pepper.
¾ cup yellow cornmeal, ¼ cup all-purpose flour, 1 ½ teaspoons garlic powder, 1 teaspoon smoked paprika, 1 teaspoon salt, ½ teaspoon black pepper
Bread the Fish: Remove the fillets from the buttermilk and let the excess drip off. Dredge each fillet in the cornmeal mixture, pressing to coat both sides evenly.
Pan Fry: Heat about ½-inch to 1-inch of oil in a large skillet over medium heat. Once hot, add 2 fillets (or however many fit without crowding). Cook 3–4 minutes per side or until golden brown and the fish flakes easily with a fork. Add more oil as needed and repeat with remaining fillets.
Vegetable oil
Serve: Drain briefly on a wire cooling rack over a paper towel-lined baking sheet. Serve warm with sides, lemon wedges, and your favorite dipping sauce.